Melatonin

Big fan of melatonin supplementation for a number of reasons, but just as a quick aside, the levels of melatonin that are in most supplements are far too high to really be considered physiological. They are indeed supraphysiological, in most cases, and melatonin can have a number of different effects, not just related to sleep, but that's supplemented melatonin.Andrew Huberman:Here I'm talking about our natural production and release of melatonin according to where we are in the 365-day-calendar year. Endogenous melatonin, meaning the melatonin that we make within our bodies naturally, not melatonin that's supplemented, has two general categories of effects. The first set of effects are so-called regulatory effects, and the others are protective effects. The regulatory effects are, for instance, that melatonin can positively impact bone mass. So melatonin can, for instance, turn on the production of osteoblasts, which are essentially stem cells that make more bone for us, that make our bone stronger, and that can replace damaged aspects of our bone.Andrew Huberman:Melatonin is also involved in maturation of the gonads during puberty, the ovaries and the testes. Although there the effects of melatonin tend to be suppressive on maturation of the ovaries and testes, meaning high levels of melatonin tend to reduce testicle volume and reduce certain functions within the testes, including sperm production and testosterone production. And within the ovaries, melatonin can suppress the maturation of eggs, et cetera.Andrew Huberman:Now, I don't want anyone to get scared if you've been taking melatonin, mostly effects of melatonin on those functions are reversible. But I should point out that one of the reasons why children don't go into puberty until a particular age is that young children tend to have chronically high endogenous melatonin, and that is healthy, to keep them out of puberty until it's the right time for puberty to happen. So melatonin can increase bone mass, but reduces gonad mass, so to speak.Andrew Huberman:It's going to have varying effects depending on the ratios and levels of other hormones and other biological events in the body. But as you can see, melatonin has these powerful regulatory effects on other tissues. I should also mention that melatonin is a powerful modulator of placental development. So for anyone that's pregnant, if you're considering melatonin supplementation, please, please, please talk to your ob-gyn; talk to your other doctors as well. You want to be very, very cautious because of the powerful effects that melatonin can have on the developing fetus and placenta.Andrew Huberman:For people that are not pregnant, in fact, all people, melatonin has a powerful effect on the central nervous system as a whole. Your brain and spinal cord are the major components of your central nervous

Through inhalation.It’s important to note that melatonin vapes are not a strong sedative or sleep aid. They are meant to help you relax and achieve better sleep. Each puff of Cloudy melatonin vape contains 0.5mg of melatonin. The recommended dose for an individual is anywhere from 0.5mg to 5mg, so it’s not beyond the recommended limit of 5mg.Overall, inhaling melatonin is perfectly safe, as long as the vape pens contain no nicotine, vitamin E acetate, nor any other harmful substance – and Cloudy has none of these. However, it’s always best to consult with a healthcare professional before trying any new sleep aid, including melatonin vapes.Our Recommend9.7 SPIRITBAR TRON 20000 Puffs $14.99 (Free Shipping, 2-6 Days Delivery)Full-Screen DisplaySmooth & Boost Adjustable Two Models25ml E-liquid Capacity50mg StrengthUp to 20000 PuffsSafety of VapingWhen it comes to vaping melatonin, safety concerns have been raised by experts. While vaping melatonin is marketed as a fast-acting sleep aid, it is important to understand the potential risks involved.Firstly, melatonin vapes are unregulated products, which means that there is no oversight on the quality or safety of the product. This can lead to inconsistencies in the amount of melatonin in each puff, which could result in an accidental overdose.Additionally, vaping in general has been linked to lung damage and respiratory issues. While melatonin vapes are marketed as safe, there is still a lack of research on the long-term effects of inhaling melatonin vapor.It is also important to note that melatonin vapes should not be used as a substitute for proper sleep hygiene. While they may provide short-term relief for insomnia, they do not address the underlying causes of sleep issues.In summary, while melatonin vapes may seem like a convenient and fast-acting sleep aid, there are potential risks involved. It is important to consider the lack of regulation, potential overdose, and long-term effects on respiratory health before deciding to use a melatonin vape.Effects of Melatonin on the BodyMelatonin is a hormone that is naturally produced by the pineal gland in the brain. It helps regulate the sleep-wake cycle and is commonly used as a sleep aid. However, when taken in large amounts or in the wrong form, melatonin can have negative effects on the body.Some of the common side effects of melatonin include dizziness, headache, nausea, and drowsiness. It can also cause changes in blood pressure, body temperature, and heart rate. In rare cases, melatonin can cause seizures, hallucinations, and other serious side effects.When it comes to melatonin vapes, there is not enough research to determine their safety and effectiveness. The use of vaping devices to deliver melatonin is relatively new, and there is limited information on the long-term effects of inhaling melatonin.It is important to talk to

To have high melatonin levels naturally. For adultsThere's no official suggested dose for melatonin, but most people take between 1 and 5 milligrams about 30 minutes before bed. Supplements are available in doses ranging from 200 micrograms to 20 milligrams. Experts suggest starting with a low dose, such as 1 milligram or less, and raising it only if needed. Lower doses can work as well as higher ones, but the right dose may vary based on things such as your age.For childrenWhile melatonin supplements are likely safe for children, you should talk to your family doctor first. The dose for kids with insomnia usually depends on their age. Preschoolers can often take 1 to 2 milligrams, school-aged children 1 to 3 milligrams, and adolescents 1 to 5 milligrams. Since melatonin is a hormone and researchers haven't closely studied it in children, there’s a concern it could affect hormonal development.Doctors can check your melatonin levels by doing blood or urine tests, which show how much melatonin is in your body. Some tests use a small saliva (spit) sample. Normal melatonin levelsMelatonin levels in the pineal gland change based on your age and sex. Here's what they can look like throughout your life:Newborns. Babies don't make their own melatonin. Before birth, they get it from the placenta and, after birth, through breast milk. Melatonin production starts when they are 2 to 3 months old.Children. Melatonin levels rise as you grow, peaking just before puberty.Puberty. After puberty begins, melatonin levels drop steadily until they level off in your late teens.After puberty. Women and people assigned female at birth (AFAB) have higher melatonin levels than men and people assigned male at birth (AMAB).Middle age. Melatonin levels stay stable until around age 40, then begin to fall.Older adulthood. Melatonin levels in people over 90 are

Many people know of melatonin as the sleep hormone – and, indeed, that’s what most of the research on melatonin has focused on. However, melatonin is also an antioxidant, protecting cells from harmful “free radicals” that can damage DNA – and this includes protecting cells in the heart and blood vessels.Given that heart disease is the leading cause of death in the world, killing around 17.9 million people each year, this action is of particular interest to researchers.Research shows that people with cardiovascular disease have lower levels of melatonin in their blood compared with healthy people. And there is a strong inverse relationship between melatonin levels and cardiovascular disease. In other words, the lower a person’s melatonin level, the higher their risk of cardiovascular disease. Melatonin supplements (2.5mg taken one hour before sleep) have been shown to reduce blood pressure. And, of course, high blood pressure (hypertension) is a known risk factor for cardiovascular disease. Also, so-called cardiovascular events, including heart attacks and sudden cardiac death (unexpected death caused by a change in heart rhythm), occur at a higher rate in the early morning when melatonin is at its lowest. These studies strongly suggest that melatonin protects the heart and blood vessels. Heart attacks are more common in the morning when melatonin is at its lowest. Ko Backpacko/Shutterstock Importantly, patients who have had a heart attack have reduced nighttime melatonin levels. This observation has led to the theory that melatonin may be able to improve recovery from a heart attack